MovDisordV3, Main, Exploration, bibRecord, 002E15

Higher nigrostriatal dopamine neuron loss in early than late onset Parkinson's disease?—A [99mTc]‐TRODAT‐1 SPECT study

Identifieur interne : 002E15 ( Main/Exploration ); précédent : 002E14; suivant : 002E16

Higher nigrostriatal dopamine neuron loss in early than late onset Parkinson's disease?—A [99mTc]‐TRODAT‐1 SPECT study

Auteurs : Ming Chi Shih [Brésil] ; Luiz Augusto Franco De Andrade [Brésil] ; Edson Amaro Jr [Brésil] ; Andre Carvalho Felicio [Brésil] ; Henrique Ballalai Ferraz [Brésil] ; Jairo Wagner [Brésil] ; Marcelo Queiroz Hoexter [Brésil] ; Li Fu Lin [République populaire de Chine] ; Ying Kai Fu [République populaire de Chine] ; Jair Jesus Mari [Brésil] ; Sergio Tufik [Brésil] ; Rodrigo Affonseca Bressan [Brésil]

Source :

Movement Disorders [ 0885-3185 ] ; 2007-04-30.

RBID : ISTEX:A913CA6EC215132493DC2EC8F7A520CF7763E9EB

Descripteurs français

Pascal (Inist)
- Dopamine, Mort cellulaire, Parkinson maladie, Photon, Système nerveux pathologie, Tomoscintigraphie émission monophotonique.

English descriptors

KwdEn :
- Adult, Age of Onset, Aged, Cell death, Corpus Striatum (radionuclide imaging), Depression (epidemiology), Dopamine, Dopamine (analysis), Female, Humans, Male, Middle Aged, Nervous system diseases, Organotechnetium Compounds (diagnostic use), Parkinson Disease (psychology), Parkinson Disease (radionuclide imaging), Parkinson disease, Photon, Radiopharmaceuticals (diagnostic use), SPECT, Single photon emission tomography, Substantia Nigra (radionuclide imaging), TRODAT, Tomography, Emission-Computed, Single-Photon, Tropanes (diagnostic use), dopamine transporter, early and late onset Parkinson's disease.
MESH :
- chemical , analysis : Dopamine.
- chemical , diagnostic use : Organotechnetium Compounds, Radiopharmaceuticals, Tropanes.
- epidemiology : Depression.
- psychology : Parkinson Disease.
- radionuclide imaging : Corpus Striatum, Parkinson Disease, Substantia Nigra.
- Adult, Age of Onset, Aged, Female, Humans, Male, Middle Aged, Tomography, Emission-Computed, Single-Photon.

Abstract

Early‐onset Parkinson's disease (EOPD) is distinct from the classic late‐onset PD (LOPD) because of its slower disease progression. The aim of this study was to compare dopamine neuronal loss in EOPD with that of LOPD with the same disease duration, through dopamine transporter (DAT) estimation. Fourteen patients, seven EOPD (<50 years) and seven LOPD, matched for disease duration were scanned with [99mTc]‐TRODAT‐1‐SPECT (INER‐Taiwan), and were assessed with standard PD scales. EOPD patients had 34% lower striatal DAT binding potential (BP) compared with that of LOPD patients (BP = 0.29 ± 0.12, BP = 0.44 ± 0.12, P < 0.02) with similar PD severity. These results suggest that EOPD patients have greater dopamine density loss than LOPD patients without motor‐symptom worsening. © 2007 Movement Disorder Society

Url:

https://api.istex.fr/document/A913CA6EC215132493DC2EC8F7A520CF7763E9EB/fulltext/pdf

DOI: 10.1002/mds.21315

Affiliations:

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Age of Onset</term>
<term>Aged</term>
<term>Cell death</term>
<term>Corpus Striatum (radionuclide imaging)</term>
<term>Depression (epidemiology)</term>
<term>Dopamine</term>
<term>Dopamine (analysis)</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Nervous system diseases</term>
<term>Organotechnetium Compounds (diagnostic use)</term>
<term>Parkinson Disease (psychology)</term>
<term>Parkinson Disease (radionuclide imaging)</term>
<term>Parkinson disease</term>
<term>Photon</term>
<term>Radiopharmaceuticals (diagnostic use)</term>
<term>SPECT</term>
<term>Single photon emission tomography</term>
<term>Substantia Nigra (radionuclide imaging)</term>
<term>TRODAT</term>
<term>Tomography, Emission-Computed, Single-Photon</term>
<term>Tropanes (diagnostic use)</term>
<term>dopamine transporter</term>
<term>early and late onset Parkinson's disease</term>
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<keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Organotechnetium Compounds</term>
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<term>Tropanes</term>
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<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term>
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<term>Age of Onset</term>
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<term>Male</term>
<term>Middle Aged</term>
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<term>Mort cellulaire</term>
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<front><div type="abstract" xml:lang="en">Early‐onset Parkinson's disease (EOPD) is distinct from the classic late‐onset PD (LOPD) because of its slower disease progression. The aim of this study was to compare dopamine neuronal loss in EOPD with that of LOPD with the same disease duration, through dopamine transporter (DAT) estimation. Fourteen patients, seven EOPD (<50 years) and seven LOPD, matched for disease duration were scanned with [99mTc]‐TRODAT‐1‐SPECT (INER‐Taiwan), and were assessed with standard PD scales. EOPD patients had 34% lower striatal DAT binding potential (BP) compared with that of LOPD patients (BP = 0.29 ± 0.12, BP = 0.44 ± 0.12, P < 0.02) with similar PD severity. These results suggest that EOPD patients have greater dopamine density loss than LOPD patients without motor‐symptom worsening. © 2007 Movement Disorder Society</div>
</front>
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<affiliations><list><country><li>Brésil</li>
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Movement Disorders (revue)

Higher nigrostriatal dopamine neuron loss in early than late onset Parkinson's disease?—A [99mTc]‐TRODAT‐1 SPECT study

Higher nigrostriatal dopamine neuron loss in early than late onset Parkinson's disease?—A [99mTc]‐TRODAT‐1 SPECT study

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

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	Movement Disorders (revue)
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